Is Cholibrium Legit & Safe? Ingredients, Dosage & Side Effects
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Short answer: Yes, Cholibrium is a legitimate supplement from Simple Promise Pte. Ltd., delivering 1,330 mg of 10 mushrooms per two-capsule serving for normal-range lipid and heart support in adults 40+. ClickBank orders include one-time billing, free US shipping, and a 365-day money-back guarantee — even on empty bottles. Still, it cannot replace statins: six fungi share one 266 mg blend, no trial tests the finished capsule, and blood-thinner or kidney-stone patients need physician clearance first.
Quick answers: Cholibrium legitimacy, dosage, and safety
Question | Verified answer (November 2026) |
Is Cholibrium legit? | Yes — vegan capsule by Simple Promise Pte. Ltd. (Camas, WA support; Maryland returns) |
What is it used for? | Antioxidant and normal-range lipid support for adults 40+ alongside healthy habits |
Daily dosage | 2 capsules (1,330 mg) with 8 oz. water, 20–30 minutes before a meal |
Label catch | Four fungi at 266 mg each; six share one 266 mg blend (exact mg not disclosed) |
Key safety risks | Blood thinners/aspirin (Wood Ear), kidney stones (Chaga), or quitting statins solo |
Price & refund | $39–$59/bottle (one-time ClickBank charge, free US shipping) + 365-day refund |
Is Cholibrium legit? Company, label audit, and complaints
Adults 45+ asking "is Cholibrium legit?" want to verify the company, the label, and the refund promise. Our November 8, 2026 audit found:
Verified US fulfillment. Sold by Simple Promise Pte. Ltd. (Truegenics), with US support at 3242 NE 3rd Avenue #1051, Camas, WA 98607 (1-800-259-9522), cGMP production, and ClickBank checkout (1-800-390-6035).
NIH DSLD white-label twin. The NIH Dietary Supplement Label Database (DSLD) lists zero entries under "Cholibrium" or "Simple Promise." Yet its 5 × 266 mg panel and excipients (cellulose capsule, microcrystalline cellulose, magnesium stearate) match stock labels on NIH DSLD like Aceworkz Mushroom 10X Complex (ID 258787) — and its bottle image is named Cholibrium(mushroom10x). Higher pricing funds the 365-day refund net and eBooks.
Sales-copy gaps. Sales copy hints at a bedtime food statin, yet lovastatin came from Aspergillus terreus and red yeast rice — neither is in Cholibrium — and capsules are taken before meals. The ClickBank lander's "View References" tab also leaves Cascara sagrada and fennel links from another Simple Promise formula. Quotes ("John E. B.", "Patricia P.", "Brenda Wood") are testimonials on the seller's site, not independently verified, with names changed for privacy.
Buyer complaints (anecdotes)
Trustpilot (`mysimplepromise.com`): ~3.8–3.9 / 5 stars (~35–38 reviews) — praise for phone reps (1-800-259-9522) on returns, alongside 1-star posts over long video ads, modest 30-day shifts, or optional "Subscribe & Save" charges on Simple Promise's Shopify site.
BBB (`Camas, WA`): A rating (not accredited), with 4 complaints in 3 years (0 in the past year) over delivery or expectations, marked answered or resolved.
Reddit & resellers: Almost zero independent Reddit lipid logs; Amazon, eBay, and Walmart resellers are unauthorized and lack refund coverage.
What is Cholibrium used for — and how can mushrooms affect lipids?
Cholibrium targets adults 40+ seeking plant-based support for normal-range cholesterol and triglycerides alongside diet and exercise.
Bile-acid binding: Your liver turns cholesterol into bile acids (NHLBI, NIH). Mushroom beta-glucans bind gut bile acids for excretion, nudging LDL clearance — though fiber LDL drops require 3,000–10,000 mg/day, versus 1,330 mg total here (beta-glucan % not disclosed).
Antioxidants: Across 7 observational studies, mushroom intake correlated with favorable triglyceride and BP trends, without RCTs proving fewer heart events (Krittanawong et al., 2021).
Compare it with plant sterols and psyllium in our Cholibrium review and VenoPlus 8 cardiovascular review.
Cholibrium ingredients and dosage: full 1,330 mg breakdown
Each bottle holds 60 vegan capsules (30 servings): take two daily with 8 oz. water, 20–30 minutes before a meal (non-GMO, gluten-free, odorless).
No trial tests Cholibrium itself. Its 1,330 mg serving splits into four 266 mg fungi plus one 266 mg blend shared by six fungi (~44 mg each; exact weights not disclosed):
Mushroom & label dose | PubMed human research (sample, dose, outcome) | Lipid evidence |
Cordyceps (C. sinensis powder, 266 mg) | RCT in 20 older adults (999 mg/day, 12 wks) raised lactate threshold 10.5% (Chen et al., 2010). No human lipid RCT. | None |
Reishi (G. lucidum extract, 266 mg) | Cochrane review (5 RCTs, 398 adults, 1.4–3 g/day) found no LDL, TC, TG, or BP drop (Klupp et al., 2015). | Neutral |
Shiitake (L. edodes extract, 266 mg) | RCT in 68 borderline-high-lipid adults eating Shiitake bars (66 days) cut TG 10%, not LDL (Spim et al., 2021). Eritadenine mg not disclosed. | Limited (TG) |
Lion's Mane (H. erinaceus, 266 mg) | No human cholesterol trials (rodent data only). | Animal-only |
Maitake (G. frondosa, 266 mg blend) | Mg not disclosed; no human lipid trials (mouse data only). | Animal-only |
Turkey Tail (T. versicolor, 266 mg blend) | Mg not disclosed; no human lipid trials. | None |
Chaga (I. obliquus, 266 mg blend) | Mg not disclosed; no human lipid trials (mouse data only). | Animal-only |
Royal Agaricus (A. blazei, 266 mg blend) | Mg not disclosed; RCT in 72 diabetes adults (1,500 mg/day) aided insulin resistance (Hsu et al., 2007). | Glucose only |
White Button (A. bisporus, 266 mg blend) | Mg not disclosed; 1-yr RCT in 73 obese adults swapping mushrooms for meat cut weight (-7 lbs) and BP (Poddar et al., 2013). | Food swap |
Wood Ear (A. auricula, 266 mg blend) | Mg not disclosed; no human lipid RCT; inhibits human platelets in vitro (Agarwal et al., 1982). | Preclinical |
Even where human trials showed metabolic shifts (see mushrooms and blood sugar balance), doses were 5–30× larger than Cholibrium's per-fungus amounts.
Is Cholibrium safe? Side effects, statins, and drug interactions
Supplements are unreviewed by the FDA before sale (FDA: Supplements). Review these risks with your doctor or pharmacist first (FDA: Mixing Medications):
GI upset or rash: Reishi RCTs noted occasional mild stomach upset, loose stools, or dry mouth (Klupp et al., 2015). In the Shiitake trial, 10% of sensitive adults developed dermatitis (Spim et al., 2021).
Statins (atorvastatin, rosuvastatin, simvastatin): Never quit statins solo — stopping rebounds LDL and heart risk. Ask your doctor before combining them.
Blood thinners and aspirin (warfarin, Eliquis, Xarelto, Plavix): 1,500 mg/day Reishi did not alter clotting in 40 healthy volunteers (Kwok et al., 2005), yet anticoagulant users were excluded — and Wood Ear inhibits human platelets (Agarwal et al., 1982). Skip on blood thinners; stop 2 weeks pre-surgery.
Kidney stones or CKD: High-oxalate Chaga caused acute oxalate kidney injury in a 69-year-old man (Kwon et al., 2022). Avoid with CKD or kidney stones.
Diabetes/BP meds, pregnancy, nursing, autoimmune disease, or under 18: Monitor glucose and BP (Hsu et al., 2007); skip if pregnant, nursing, immunocompromised, or under 18.
When to see a doctor: Call 911 for chest pain/pressure, arm/jaw pain, shortness of breath, or slurred speech. Book a prompt visit for LDL ≥ 190 mg/dL (NHLBI, NIH), statin muscle pain, or unusual bruising. Pair care with how to maintain cardiovascular health naturally and essential steps to improve cardiovascular health.
Cholibrium pricing, one-time billing, and 365-day refund rules
On November 8, 2026, Simple Promise's ClickBank page listed three tiers:
Package | Supply | Total | Per bottle | US shipping | Bonuses |
1 Bottle | 30 days (60 caps) | $59 | $59 | Free | None |
3 Bottles | 90 days (180 caps) | $147 | $49 | Free | 3 eBooks ($161 value) |
6 Bottles | 180 days (360 caps) | $234 | $39 | Free | 3 eBooks ($161 value) |
One-time ClickBank billing: Single charge with free 5–7 business-day DHL US shipping (unlike Simple Promise's optional Shopify "Subscribe & Save" box).
365-day returns: Mail all bottles (unused, partly used, or empty) at your postage cost, with Name and Order ID#, to Simple Promise Returns Centre, c/o SISK Fulfillment Service, 1900 Industrial Park Road, PO Box 463, Federalsburg, MD 21632, and send tracking to support@mysimplepromise.com, 1-800-259-9522, or clkbank.com.
FAQ
What are the 10 mushrooms in Cholibrium? Cordyceps, Reishi, Shiitake, Lion's Mane, Maitake, Turkey Tail, Chaga, Royal Sun Agaricus, White Button, and Black Fungus (Wood Ear).
How much mushroom extract is in each serving of Cholibrium? Two capsules supply 1,330 mg: 266 mg each of Cordyceps, Reishi, Shiitake, and Lion's Mane, plus one 266 mg blend for the other six fungi (exact weights and beta-glucan % not disclosed).
Is Cholibrium vegan and gluten-free? Yes — plant-cellulose capsules with microcrystalline cellulose and vegetable magnesium stearate; vegan, non-GMO, and gluten-free.
Are there any side effects associated with Cholibrium? Reishi and Shiitake studies note occasional mild stomach upset, loose stools, dry mouth, or rash in ~10% of Shiitake-sensitive adults.
Can Cholibrium be taken with statins or blood thinners? Skip on blood thinners or daily aspirin unless physician-cleared (Wood Ear inhibits platelets). Never stop statins solo; ask your doctor first.
Does Cholibrium have an auto-billing subscription? No on ClickBank checkout — all bundles are one-time charges. Only Simple Promise's Shopify store has an optional "Subscribe & Save" box.
How does the Cholibrium 365-day money-back guarantee work? Return all bottles (even empty) with your Name and Order ID# to Federalsburg, MD within 365 days; you pay return postage for a full refund.
Sources
NIH ODS. DSLD: Aceworkz Mushroom 10X Complex (ID 258787). https://dsld.od.nih.gov/label/258787
Klupp NL, et al. Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors. Cochrane Database Syst Rev. 2015. https://pubmed.ncbi.nlm.nih.gov/25686270/
Spim SRV, et al. Effects of Shiitake Culinary-Medicinal Mushroom, Lentinus edodes, Bars on Lipid and Antioxidant Profiles in Individuals with Borderline High Cholesterol: A Double-Blind Randomized Clinical Trial. Int J Med Mushrooms. 2021. https://pubmed.ncbi.nlm.nih.gov/34375514/
Chen S, et al. Effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy older subjects: a double-blind, placebo-controlled trial. J Altern Complement Med. 2010. https://pubmed.ncbi.nlm.nih.gov/20804368/
Kwon O, et al. Chaga mushroom-induced oxalate nephropathy that clinically manifested as nephrotic syndrome: A case report. Medicine (Baltimore). 2022. https://pubmed.ncbi.nlm.nih.gov/35451393/
Hsu CH, et al. The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med. 2007. https://pubmed.ncbi.nlm.nih.gov/17309383/
Poddar KH, et al. Positive effect of mushrooms substituted for meat on body weight, body composition, and health parameters: A 1-year randomized clinical trial. Appetite. 2013. https://pubmed.ncbi.nlm.nih.gov/24056209/
Agarwal KC, et al. Inhibition of human and rat platelet aggregation by extracts of Mo-er (Auricularia auricula). Thromb Haemost. 1982. https://pubmed.ncbi.nlm.nih.gov/6983740/
Kwok Y, et al. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. Anesth Analg. 2005. https://pubmed.ncbi.nlm.nih.gov/16037156/
Krittanawong C, et al. Mushroom Consumption and Cardiovascular Health: A Systematic Review. Am J Med. 2021. https://pubmed.ncbi.nlm.nih.gov/33309597/
NHLBI, NIH. What Is Blood Cholesterol? https://www.nhlbi.nih.gov/health/blood-cholesterol
U.S. FDA. Dietary Supplements. https://www.fda.gov/food/dietary-supplements
U.S. FDA. Mixing Medications and Dietary Supplements Can Endanger Your Health. https://www.fda.gov/consumers/consumer-updates/mixing-medications-and-dietary-supplements-can-endanger-your-health
Educational information only; not a substitute for advice from your physician or pharmacist. Statements on dietary supplements have not been evaluated by the FDA and do not diagnose, treat, manage, or prevent disease. Prices and 365-day return rules were verified on Simple Promise's order and policy pages on November 8, 2026 and may change.
